Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder characterized
by chronic inflammation and fibrosis. Rho-associated coiled-coil–containing protein kinases …

ABSTRACT Rho-associated kinase 1 (ROCK1) and ROCK2 are activated by Rho GTPase
and control cytoskeleton rearrangement through modulating the phosphorylation of their …

Patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD) have a low
one-year survival rate. Identification and validation of novel targetable kinases in patients …

PURPOSE The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling
pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways …

Chronic graft-versus-host disease (cGVHD) remains a major complication following
allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is …

Rho-associated kinase (ROCK) has been found to be involved in the pathogenesis of a
variety of autoimmune diseases, but the role of ROCK in inflammatory bowel disease (IBD) …

Rho-associated coiled-coil kinase (ROCK) 2 targeting down-regulates autoimmune
responses in animal models and patients, however the underlying molecular mechanism is …

Belumosudil (BLM) is a ROCK inhibitor that has been firstly developed by Surface Logix,
later acquired by Kadmon Pharmaceuticals for the treatment of chronic graft-versus-host …

Introduction Chronic graft-versus-host disease (cGVHD) is a complication of allogeneic
hematopoietic cell transplantation (allo-HCT) and is the main cause of late non-relapse …

Rho-associated kinase 2 (ROCK2) determines the balance between human T helper 17
(TH17) cells and regulatory T (Treg) cells. We investigated its role in the generation of T …