The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

With age, haematopoietic stem cells lose their ability to regenerate the blood system, and
promote disease development. Autophagy is associated with health and longevity, and is …

Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How
HSCs accommodate the diverse cellular stresses associated with their life-long activity …

Abstract Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of
cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the …

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few
blood cells that truly age,. Paradoxically, although HSCs numerically expand with age, their …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Chaperone-mediated autophagy (CMA) is a selective type of autophagy whereby a specific
subset of intracellular proteins is targeted to the lysosome for degradation. These proteins …

During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age,
this decline is maximal owing to transition from a normal quiescence into an irreversible …

Ageing in multicellular organisms typically involves a progressive decline in cell
replacement and repair processes, resulting in several physiological deficiencies, including …