Mechanical force controls fundamental cellular processes in health and disease, and
increasing evidence shows that the nucleus both experiences and senses applied forces …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Cell phenotype and fate are driven by the mechanical properties of their surrounding
environment. Changes in matrix rigidity or application of force have been shown to impact …

Many signaling pathways converge on the nucleus to regulate crucial nuclear events such
as transcription, DNA replication and cell cycle progression. Although the vast majority of …

Mechanical forces influence many aspects of cell behaviour. Forces are detected and
transduced into biochemical signals by force-bearing molecular elements located at the cell …

A cell's ability to react to mechanical stimuli is known to be affected by the transport of
transcription factors, the proteins responsible for regulating transcription of DNA into RNA …

Extracellular mechanical forces result in changes in gene expression, but it is unclear how
cells are able to permanently adapt to new mechanical environments because chemical …

Cells respond to mechanical signals, but the subcellular mechanisms are not well
understood. The nucleus has recently emerged as an important mechanosensory organelle …

Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular
responses that control cell fate changes. Mechanical forces also physically distort …

Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …