The structure and stability of an HLA-A* 0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site
The crystal structure of the human class I MHC molecule HLA-A2 complexed with of an
octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1 (HTLV-1) …
octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1 (HTLV-1) …
Peptide recognition by two HLA-A2/Tax11–19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures
S Hausmann, WE Biddison, KJ Smith… - The Journal of …, 1999 - journals.aai.org
The crystal structures of two human TCRs specific for a HTLV-I Tax peptide bound to HLA-
A2 were recently determined, for the first time allowing a functional comparison of TCRs for …
A2 were recently determined, for the first time allowing a functional comparison of TCRs for …
Identification of a crucial energetic footprint on the α1 helix of human histocompatibility leukocyte antigen (Hla)-A2 that provides functional interactions for recognition …
BM Baker, RV Turner, SJ Gagnon, DC Wiley… - The Journal of …, 2001 - rupress.org
Structural studies have shown that class I major histocompatibility complex (MHC)-restricted
peptide-specific T cell receptor (TCR)-α/βs make multiple contacts with the α1 and α2 …
peptide-specific T cell receptor (TCR)-α/βs make multiple contacts with the α1 and α2 …
Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia
Y Furukawa, R Kubota, M Tara… - Blood, The Journal of …, 2001 - ashpublications.org
Although Tax protein is the main target of cytotoxic T lymphocyte (CTL) on human T-cell
lymphotropic virus type I (HTLV-I)–infected cells, and Tax peptide 11 through 19 binding to …
lymphotropic virus type I (HTLV-I)–infected cells, and Tax peptide 11 through 19 binding to …
Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC …
DN Garboczi, U Utz, P Ghosh, A Seth, J Kim… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
T lymphocytes use TCR-alphabeta to bind and to recognize complexes of antigenic peptides
bound to MHC proteins located at the surface of APCs. We have assembled and crystallized …
bound to MHC proteins located at the surface of APCs. We have assembled and crystallized …
Presentation of three different viral peptides, HTLV-1 Tax, HCMV gB, and influenza virus M1, is determined by common structural features of the HLA-A2. 1 molecule.
U Utz, S Koenig, JE Coligan… - Journal of immunology …, 1992 - journals.aai.org
To determine whether similar or dissimilar molecular features of class I molecules are
involved in the presentation of structurally distinct peptides, we have investigated the …
involved in the presentation of structurally distinct peptides, we have investigated the …
Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax
S Niewiesk, S Daenke, CE Parker, G Taylor… - Journal of …, 1995 - Am Soc Microbiol
There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-
cell leukemia virus type I (HTLV-I), although the sequence variation between patients is …
cell leukemia virus type I (HTLV-I), although the sequence variation between patients is …
Crystal structures of HLA‐A* 0201 complexed with antigenic peptides with either the amino‐or carboxyl‐terminal group substituted by a methyl group
M Bouvier, HC Guo, KJ Smith… - … : Structure, Function, and …, 1998 - Wiley Online Library
The crystal structures of class I major histocompatibility complex (MHC) molecules
complexed with antigenic peptides revealed a network of hydrogen bonds between the …
complexed with antigenic peptides revealed a network of hydrogen bonds between the …
Target epitope in the Tax protein of human T-cell leukemia virus type I recognized by class I major histocompatibility complex-restricted cytotoxic T cells
M Kannagi, H Shida, H Igarashi, K Kuruma… - Journal of …, 1992 - Am Soc Microbiol
A trans-acting regulatory gene product p40tax (Tax) of human T-cell leukemia virus type I
(HTLV-I) is one of the main target antigens recognized by cytotoxic T lymphocytes (CTL) …
(HTLV-I) is one of the main target antigens recognized by cytotoxic T lymphocytes (CTL) …
Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.
P Höllsberg, WE Weber, F Dangond… - Proceedings of the …, 1995 - National Acad Sciences
Human T-cell leukemia virus type I (HTLV-I) gives rise to a neurologic disease known as
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the …
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although the …