Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Abstract Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder
characterized by senile plaques and neurofibrillary tangles, is the most common form of …

As the most abundant cell types in the brain, astrocytes form a tissue-wide signaling network
that is responsible for maintaining brain homeostasis and regulating various brain activities …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions
such as Alzheimer's disease. However, the specific role of reactive astrocytes is still …

Astrocytes were historically classified as supporting cells; however, it is becoming
increasingly clear that they actively contribute to neuronal functioning under normal and …

A growing body of research suggests that astrocytes play roles as contributors to the
pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that …

Astrocytes are thought to play a protective role in Alzheimer's disease (AD) by shielding
neurons from the toxic effects of extracellular senile plaques. The mechanisms involved in …

Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …

Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late
stage cannot be easily reversed. Because AD progression is caused by multiple factors …