Conspectus Our cellular genome is continuously exposed to a wide spectrum of exogenous
and endogenous DNA damaging agents. These agents can lead to formation of an …

Oxidative and alkylating DNA damage occurs under normal physiological conditions and
exogenous exposure to DNA damaging agents. To counteract DNA base damage, cells …

Base excision repair (BER) is the major pathway responsible for averting the mutagenic and
cytotoxic effects of spontaneous hydrolytic, oxidative, and non-enzymatic alkylation DNA …

Covalent alterations of DNA bases, which may have promutagenic or cytotoxic effects, are
major consequences of endogenous DNA damage caused by hydrolysis, reactive oxygen …

Damage to DNA bases occurs continuously in cells as a result of the intrinsic instability of
nucleic acids and because of the presence of intracellular and environmental genotoxins. As …

Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

DNA damaging agents generated as a consequence of endogenous metabolism or via
exogenous factors can produce a wide variety of lesions in DNA. These include base …

DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …

This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …

Despite the importance of DNA repair in protecting the genome, the molecular basis for
damage recognition and repair remains poorly understood. In the base excision repair …