Recent studies demonstrate that age-related dysfunction of NF-E2–related factor-2 (Nrf2)–
driven pathways impairs cellular redox homeostasis, exacerbating age-related cellular …

There is strong evidence showing that aging is associated with vascular oxidative stress,
which has been causally linked to the development of cardiovascular diseases. NF-E2 …

This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1,
provides a landscape of molecular mechanisms involved in cardiovascular alterations in …

Aging is associated with increased oxidative stress in vascular endothelial and smooth
muscle cells, which contribute to the development of a wide range of diseases affecting the …

The redox-sensitive transcription factor NF-E2–related factor 2 (Nrf2) plays a key role in
preserving a healthy endothelial phenotype and maintaining the functional integrity of the …

Aging promotes oxidative stress in vascular endothelial and smooth muscle cells, which
contribute to the development of cardiovascular diseases. NF-E2–related factor 2 (Nrf2) is a …

BACKGROUND AND AIMS: Hyperglycemia and diabetes are associated with increased
formation of advanced glycation end products and enhanced oxidative stress, leading to the …

Under normal physiological conditions, free radical generation and antioxidant defences are
balanced, and reactive oxygen species (ROS) usually act as secondary messengers in a …

Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease
development. Ageing-related vascular dysfunction involves defective antioxidant response …