DNA gyrase and topoisomerase IV (topo IV) inhibitors are among the most interesting
antibacterial drug classes without antibacterial pipeline representative. Twenty-four new …

DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule
inhibitors have been discovered in recent decades, but none of these have reached the …

Novel benzothiazole-based compounds were designed and synthesized as potential
antimicrobial agents with dual DNA gyrase/topoisomerase IV inhibitory activity. The …

A series of 3-aminoquinazolinediones was synthesized and evaluated for its antibacterial
and DNA gyrase activity. The SAR around the quinazolinedione core was explored and the …

A novel series of ciprofloxacin hybrids comprising various heterocycle derivatives has been
synthesized and structurally elucidated using 1H NMR, 13C NMR, and elementary analyses …

To develop new antimicrobial agents, a series of novel thiourea derivatives incorporated
with different moieties 2–13 was designed and synthesized and their biological activities …

New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …

The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4-
piperidyl) pyrazole 2, which has previously shown improved DNA gyrase inhibition and …

Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during
replication and are validated targets for antibacterial drug discovery. Starting from our …

DNA gyrase and topoisomerase IV are type IIa topoisomerases that are essential bacterial
enzymes required to oversee the topological state of DNA during transcription and …