Left ventricular (LV) hypertrophy commonly develops in response to chronic hypertension
and is a significant risk factor for heart failure and death. The serine-threonine phosphatase …

Estrogen has been reported to prevent development of cardiac hypertrophy in female rodent
models and in humans. However, the mechanisms of sex steroid action are incompletely …

BACKGROUND: We have shown previously that 17β-estradiol (E2) increases left ventricular
(LV) and cardiomyocyte hypertrophy after myocardial infarction (MI). However, E2 decreases …

Evidence from in vivo studies suggests that some inputs to cardiac hypertrophy are opposed
by the actions of estrogen. However, the mechanisms of E 2 action in this respect are mainly …

Background—Vascular hypertension resulting in increased cardiac load is associated with
left ventricular hypertrophy and is a leading predicator for progressive heart disease. The …

Background—Cardiac hypertrophy is a fundamental adaptive response to hemodynamic
overload; how mechanical load induces cardiac hypertrophy, however, remains elusive. It …

Background—Left ventricular hypertrophy (LVH) displays significant gender-based
differences. 17β-estradiol (E2) plays an important role in this process because it can …

Estrogen exerts complex biological effects through the two isoforms of estrogen receptors
(ERs): ERα and ERβ. Whether through alteration of gene expression or rapid, plasma …

Background Estrogen pretreatment has been shown to attenuate the development of heart
hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF) …

Estrogen has been shown to protect the heart and attenuate myocardial hypertrophy and left
ventricular remodelling through as yet to be defined mechanisms. In the present study we …