Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research

HE Park, SH Jo, RH Lee, CP Macks, T Ku… - Advanced …, 2023 - Wiley Online Library
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …

Spatial transcriptomic technologies

TY Chen, L You, JAU Hardillo, MP Chien - Cells, 2023 - mdpi.com
Spatial transcriptomic technologies enable measurement of expression levels of genes
systematically throughout tissue space, deepening our understanding of cellular …

Spatial transcriptomics in development and disease

R Zhou, G Yang, Y Zhang, Y Wang - Molecular Biomedicine, 2023 - Springer
The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like shaping intricate tissue functions and …

[HTML][HTML] Spatial transcriptomics: Technologies, applications and experimental considerations

Y Wang, B Liu, G Zhao, YJ Lee, A Buzdin, X Mu, J Zhao… - Genomics, 2023 - Elsevier
The diverse cell types of an organ have a highly structured organization to enable their
efficient and correct function. To fully appreciate gene functions in a given cell type, one …

Analysis and visualization of spatial transcriptomic data

B Liu, Y Li, L Zhang - Frontiers in Genetics, 2022 - frontiersin.org
Human and animal tissues consist of heterogeneous cell types that organize and interact in
highly structured manners. Bulk and single-cell sequencing technologies remove cells from …

Spatial transcriptomics in neuroscience

N Jung, TK Kim - Experimental & Molecular Medicine, 2023 - nature.com
The brain is one of the most complex living tissue types and is composed of an exceptional
diversity of cell types displaying unique functional connectivity. Single-cell RNA sequencing …

[HTML][HTML] A guidebook of spatial transcriptomic technologies, data resources and analysis approaches

L Yue, F Liu, J Hu, P Yang, Y Wang, J Dong… - Computational and …, 2023 - Elsevier
Advances in transcriptomic technologies have deepened our understanding of the cellular
gene expression programs of multicellular organisms and provided a theoretical basis for …

Advances in spatial transcriptomics and related data analysis strategies

J Du, YC Yang, ZJ An, MH Zhang, XH Fu… - Journal of Translational …, 2023 - Springer
Spatial transcriptomics technologies developed in recent years can provide various
information including tissue heterogeneity, which is fundamental in biological and medical …

Computational approaches and challenges in spatial transcriptomics

S Fang, B Chen, Y Zhang, H Sun, L Liu… - Genomics …, 2023 - academic.oup.com
The development of spatial transcriptomics (ST) technologies has transformed genetic
research from a single-cell data level to a two-dimensional spatial coordinate system and …

SpatialDB: a database for spatially resolved transcriptomes

Z Fan, R Chen, X Chen - Nucleic acids research, 2020 - academic.oup.com
Spatially resolved transcriptomic techniques allow the characterization of spatial
organization of cells in tissues, which revolutionize the studies of tissue function and disease …