The nervous system has a highly complex organization, including many cell types with
multiple functions, with an intricate anatomy and unique structural and functional …

In vitro systems have been proposed, but not yet demonstrated, as a method to assess the
neurotoxicity of compounds in an efficient and rapid manner. Although such tests are …

Only a small percentage of neurodegenerative diseases like Alzheimer's disease and
Parkinson's disease is directly related to familial forms. The etiology of the most abundant …

Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied
on approaches using rodent in vivo models and in vitro cell models including primary …

Detection and characterisation of chemical-induced toxic effects in the central and
peripheral nervous system represent a major challenge for employing newly developed …

It has been estimated that there are approximately 4–5 million chemical compounds in the
environment, with around 50,000–60,000 in common industrial use (1). Up to 1,000 new …

In our so far published papers, we have successfully attempted to establish stem cell-based
in vitro model systems for the study of the various aspects of DNT and have proven that …

During the last 40 years, studies incorporating in vitro methodologies have greatly advanced
our understanding of human nerve cell biology. Attempts have been made to apply these to …

The developing nervous system is highly vulnerable to the adverse effects of chemical
agents. Currently, there is an increasing need for testing and regulating chemical …

The timeline imposed by recent worldwide chemical legislation is not amenable to
conventional in vivo toxicity testing, requiring the development of rapid, economical in vitro …