Nanotopography-guided tissue engineering and regenerative medicine
Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …
Substrate topography shapes cell function
K Kulangara, KW Leong - Soft Matter, 2009 - pubs.rsc.org
Influencing cell behavior from proliferation to differentiation using substrate or implant
topography is an attractive strategy for regenerative medicine applications. Substrate …
topography is an attractive strategy for regenerative medicine applications. Substrate …
[HTML][HTML] The influence of nanotopography on cell behaviour through interactions with the extracellular matrix–A review
Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …
mediated through material-extracellular matrix interactions. The extracellular matrix that …
Nanotopographical control of stem cell differentiation
LE McNamara, RJ McMurray… - Journal of tissue …, 2010 - journals.sagepub.com
Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …
direct stem cell fate determination would have tremendous potential for basic research and …
Engineering substrate topography at the micro‐and nanoscale to control cell function
CJ Bettinger, R Langer… - Angewandte Chemie …, 2009 - Wiley Online Library
The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …
important signaling modality in controlling cell function. Naturally occurring nanotopographic …
Spatial control of adult stem cell fate using nanotopographic cues
Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …
for tissue engineering applications. However, due to the complexity of chemical and …
Cell signaling arising from nanotopography: implications for nanomedical devices
ASG Curtis, M Dalby, N Gadegaard - 2006 - Future Medicine
This review discusses the roles in signaling to cells by nanochemical, nanostructural
(nanotopography) and mechanical means, as well as recent work and trends in …
(nanotopography) and mechanical means, as well as recent work and trends in …
Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells
Inspired by ultrastructural analysis of ex vivo human tissues as well as the physiological
importance of structural density, we fabricated nanogrooves with 1: 1, 1: 3 and 1: 5 spacing …
importance of structural density, we fabricated nanogrooves with 1: 1, 1: 3 and 1: 5 spacing …
Nanoscale tissue engineering: spatial control over cell-materials interactions
Cells interact with the surrounding environment by making tens to hundreds of thousands of
nanoscale interactions with extracellular signals and features. The goal of nanoscale tissue …
nanoscale interactions with extracellular signals and features. The goal of nanoscale tissue …
Toward customized extracellular niche engineering: progress in cell‐entrapment technologies
The primary aim in tissue engineering is to repair, replace, and regenerate dysfunctional
tissues to restore homeostasis. Cell delivery for repair and regeneration is gaining impetus …
tissues to restore homeostasis. Cell delivery for repair and regeneration is gaining impetus …