Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

Z Zhang, DJ Leong, L Xu, Z He, A Wang… - Arthritis research & …, 2016 - Springer
Background Curcumin has been shown to have chondroprotective potential in vitro.
However, its effect on disease and symptom modification in osteoarthritis (OA) is largely …

A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators

M Yabas, C Orhan, B Er, M Tuzcu, AS Durmus… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a chronic and debilitating disease of the knee joint. OA of the knee is
initiated by physical damage and accumulated oxidative stress, followed by an exaggerated …

Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes

M Mathy-Hartert, I Jacquemond-Collet, F Priem… - Inflammation …, 2009 - Springer
Objective and design This study aims to investigate the effects of curcumin (Cur) on the
extracellular matrix protein metabolism of articular chondrocytes and on their production of …

[HTML][HTML] Biological actions of curcumin on articular chondrocytes

Y Henrotin, AL Clutterbuck, D Allaway… - Osteoarthritis and …, 2010 - Elsevier
OBJECTIVES: Curcumin (diferuloylmethane) is the principal biochemical component of the
spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and …

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and …

C Csaki, A Mobasheri, M Shakibaei - Arthritis research & therapy, 2009 - Springer
Introduction Currently available treatments for osteoarthritis (OA) are restricted to
nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only …

Curcumin prevents osteoarthritis by inhibiting the activation of inflammasome NLRP3

Y Sun, W Liu, H Zhang, H Li, J Liu, F Zhang… - Journal of Interferon & …, 2017 - liebertpub.com
Curcumin has shown protective potential on osteoarthritis. However, its effect on treatment of
osteoarthritis remains elusive so far. This study aimed to determine whether curcumin could …

The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis

KY Chin - Drug design, development and therapy, 2016 - Taylor & Francis
Osteoarthritis is a degenerative disease of the joint affecting aging populations worldwide. It
has an underlying inflammatory cause, which contributes to the loss of chondrocytes …

Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment

C Buhrmann, A Mobasheri, U Matis… - Arthritis research & …, 2010 - Springer
Introduction Osteoarthritis (OA) and rheumatoid arthritis (RA) are characterised by joint
inflammation and cartilage degradation. Although mesenchymal stem cell (MSC)-like …

Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management

Y Henrotin, F Priem, A Mobasheri - Springerplus, 2013 - Springer
The management of osteoarthritis represents a real challenge. This complex and multi-
factorial disease evolves over decades and requires not only the alleviation of symptoms, ie …

Curcumin inhibits apoptosis of chondrocytes through activation ERK1/2 signaling pathways induced autophagy

X Li, K Feng, J Li, D Yu, Q Fan, T Tang, X Yao, X Wang - Nutrients, 2017 - mdpi.com
Osteoarthritis (OA) is an inflammatory disease of load-bearing synovial joints that is currently
treated with drugs that exhibit numerous side effects and are only temporarily effective in …