ABSTRACT A major advantage of DNA vaccination is the ability to induce both humoral and
cellular immune responses. DNA vaccines are currently used in veterinary medicine, but …

Since the discovery, over a decade and a half ago, that genetically engineered DNA can be
delivered in vaccine form and elicit an immune response, there has been much progress in …

We have focused our research on understanding the basic biology of and developing novel
therapeutic and prophylactic DNA vaccines. We have among others three distinct primary …

Despite many years of research, human DNA vaccines have yet to fulfill their early promise.
Over the past 15 years, multiple generations of DNA vaccines have been developed and …

The promise of DNA vaccines is as compelling today as it was more than a decade ago.
Ease of manufacture, stability at ambient temperatures without the need for a cold chain and …

In the two decades since their initial discovery, DNA vaccines technologies have come a
long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still …

DNA vaccines have been widely used in efforts to develop vaccines against various
pathogens as well as for cancer, autoimmune diseases and allergy. DNA vaccines offer …

The development and widespread use of vaccines against infectious agents have been a
great triumph of medical science. One reason for the success of currently available vaccines …

It was discovered almost 20 years ago that plasmid DNA, when injected into the skin or
muscle of mice, could induce immune responses to encoded antigens. Since that time, there …

The field of DNA vaccines continues to advance and several new strategies to augment the
immunogenicity of DNA vaccines are under evaluation. The majority of these studies are in …