Patients receiving thoracic radiation often develop pulmonary injury and fibrosis. Currently,
there are no effective measures to prevent or treat these conditions. We tested whether …

Lung exposure to radiation induces an injury response that includes the release of cytokines
and chemotactic mediators; these signals recruit immune cells to execute inflammatory and …

Pulmonary fibrosis is caused by various known and unknown aetiologies, but the key
pathogenic mechanisms are still ill-defined. Chemokines are a large family of chemotactic …

Abstract Johnston, CJ, Williams, JP, Okunieff, P. and Finkelstein, JN Radiation-Induced
Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor Families. Radiat …

The mechanisms leading to the radiation-induced lung responses of alveolitis and fibrosis
are largely unknown. Herein we investigated whether CXC receptor 1 and 2 antagonism …

Aims: Radiation-induced normal tissue toxicity often precludes the application of curative
radiation doses. Here we investigated the therapeutic potential of chemokine CC motif …

Background A devastating late injury caused by radiation is pulmonary fibrosis. This risk
may limit the volume of irradiation and compromise potentially curative therapy. Therefore …

MCP-1, which signals via the CC chemokine receptor 2 (CCR2), is induced in lung fibrosis
that is accompanied by mononuclear cell recruitment and activation of lung fibroblasts. To …

We have previously shown that mice that are genetically deficient in the CCR2 gene
(CCR2−/− mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis …

Fibrosis, characterized by the accumulation of collagen, is a consequence of a chronic
inflammatory response. The purpose of this study was to determine if the mRNA expression …