Trojan-horse mechanism in the cellular uptake of silver nanoparticles verified by direct intra-and extracellular silver speciation analysis

IL Hsiao, YK Hsieh, CF Wang, IC Chen… - … science & technology, 2015 - ACS Publications
The so-called “Trojan-horse” mechanism, in which nanoparticles are internalized within cells
and then release high levels of toxic ions, has been proposed as a behavior in the cellular …

Quantification of the uptake of silver nanoparticles and ions to HepG2 cells

S Yu, J Chao, J Sun, Y Yin, J Liu… - Environmental science & …, 2013 - ACS Publications
The toxic mechanism of silver nanoparticles (AgNPs) is still debating, partially because of
the common co-occurrence and the lack of methods for separation of AgNPs and Ag+ in …

Size-Dependent Toxicity of Silver Nanoparticles to Bacteria, Yeast, Algae, Crustaceans and Mammalian Cells In Vitro

A Ivask, I Kurvet, K Kasemets, I Blinova, V Aruoja… - PloS one, 2014 - journals.plos.org
The concept of nanotechnologies is based on size-dependent properties of particles in the 1–
100 nm range. However, the relation between the particle size and biological effects is still …

Fast intracellular dissolution and persistent cellular uptake of silver nanoparticles in CHO-K1 cells: implication for cytotoxicity

X Jiang, T Miclăuş, L Wang, R Foldbjerg… - …, 2015 - Taylor & Francis
Toxicity of silver nanoparticles (Ag NPs) has been reported both in vitro and in vivo.
However, the intracellular stability and chemical state of Ag NPs are still not very well …

Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol

V De Matteis, MA Malvindi, A Galeone… - … , Biology and Medicine, 2015 - Elsevier
Toxicity of silver nanoparticles (AgNPs) is supported by many observations in literature, but
no mechanism details have been proved yet. Here we confirm and quantify the toxic …

An insight into silver nanoparticles bioavailability in rats

J Jiménez-Lamana, F Laborda, E Bolea… - Metallomics, 2014 - academic.oup.com
A comprehensive study of the bioavailability of orally administered silver nanoparticles
(AgNPs) was carried out using a rat model. The silver uptake was monitored in liver and …

Silver nanoparticles in the environment

S Yu, Y Yin, J Liu - Environmental Science: Processes & Impacts, 2013 - pubs.rsc.org
Silver nanoparticles (AgNPs) are well known for their excellent antibacterial ability and
superior physical properties, and are widely used in a growing number of applications …

Toxicological studies on silver nanoparticles: challenges and opportunities in assessment, monitoring and imaging

MC Stensberg, Q Wei, ES McLamore… - …, 2011 - Taylor & Francis
Silver nanoparticles (Ag NPs) are becoming increasingly prevalent in consumer products as
antibacterial agents. The increased use of Ag NP-enhanced products may lead to an …

The toxicity of silver nanoparticles depends on their uptake by cells and thus on their surface chemistry

E Caballero‐Díaz, C Pfeiffer, L Kastl… - Particle & Particle …, 2013 - Wiley Online Library
A set of three types of silver nanoparticles (Ag NPs) are prepared, which have the same Ag
cores, but different surface chemistry. Ag cores are stabilized with mercaptoundecanoic acid …

Cellular binding, uptake and biotransformation of silver nanoparticles in human T lymphocytes

A Malysheva, A Ivask, CL Doolette, NH Voelcker… - Nature …, 2021 - nature.com
Our knowledge of uptake, toxicity and detoxification mechanisms as related to
nanoparticles'(NPs') characteristics remains incomplete. Here we combine the analytical …