Aim Relatively little information is available about the effect of an acute exertional heat
stroke (EHS) on myocardium structure and function. Herein, we used a survival male rat …

Key points Exposure to exertional heat stroke (EHS) is associated with increased risk of long‐
term cardiovascular disorders in humans. We demonstrate that in female mice, severe EHS …

Epidemiological studies report higher risks of cardiovascular disease in humans exposed to
heat stroke earlier in life. Previously, we explored mechanistic links between heat stroke and …

It is likely that the pathophysiology of exertional heat stroke (EHS) differs from passive heat
stroke (PHS), but this has been difficult to verify experimentally. C57Bl/6 mice were …

Heat stroke is the most severe manifestation of heat-related illnesses. Classic heat stroke
(CHS), also known as passive heat stroke, occurs at rest, whereas exertional heat stroke …

Exertional heat stroke (EHS) is a potentially lethal condition resulting from high core body
temperatures (TC) in combination with a systemic inflammatory response syndrome (SIRS) …

Exertional heat stroke (EHS) is a life-threatening illness that can lead to negative health
outcomes. Using a “severe” preclinical mouse model of EHS, we tested the hypotheses that …

Heatstroke, defined as an elevated core body temperature above 40 C accompanied by
altered mental status (eg, confusion, disorientation, seizure and coma), is the most severe …

Background Heatstrokes are a serious threat to human health, particularly the
cardiovascular system. Understanding the clinical features and risk factors related to death …

Multiorgan failure is a catastrophic consequence of heat stroke (HS) and considered the
underlying etiology of mortality. Identifying novel biomarkers capable of predicting the extent …