Cilia and flagella are highly conserved microtubule (MT)-based organelles with motile and
sensory functions, and ciliary defects have been linked to several human diseases. The 9+ 2 …

Ciliary motility is crucial for the development and health of many organisms. Motility depends
on the coordinated activity of multiple dynein motors arranged in a precise pattern on the …

The nexin–dynein regulatory complex (N-DRC) is proposed to coordinate dynein arm
activity and interconnect doublet microtubules. Here we identify a conserved region in DRC4 …

The directional flow generated by motile cilia and flagella is critical for many processes,
including human development and organ function. Normal beating requires the control and …

Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a
process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are …

Cilia and flagella are highly conserved motile and sensory organelles in eukaryotes, and
defects in ciliary assembly and motility cause many ciliopathies. The two-headed I1 inner …

Motile cilia and flagella are highly conserved organelles that play important roles in human
health and development. We recently discovered a calmodulin-and spoke-associated …

In motile cilia, a mechanoregulatory network is responsible for converting the action of
thousands of dynein motors bound to doublet microtubules into a single propulsive …

Dyneins are large microtubule-based motors that power a wide variety of cellular processes.
Here we report a 4.5-Å X-ray crystallographic analysis of the entire functional motor domain …

Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key
roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein …