Age of onset defines two distinct profiles of atopic dermatitis in adults
P Facheris, JC Da Rosa, AD Pagan, M Angelov… - Allergy, 2023 - Wiley Online Library
Background The incidence of adult‐onset atopic dermatitis (AOAD) is increasing. However,
the unique characteristics of AOAD compared to pediatric‐onset AD persisting into …
the unique characteristics of AOAD compared to pediatric‐onset AD persisting into …
Adult-onset atopic dermatitis: presentations and progress
AR Chan, VK Sandhu, AM Drucker… - Journal of …, 2020 - journals.sagepub.com
Atopic dermatitis (AD) is a chronic skin disease characterized by barrier dysfunction and
immune dysregulation that affects approximately 20% of children and 2-5% of adults …
immune dysregulation that affects approximately 20% of children and 2-5% of adults …
Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis
Background Atopic dermatitis (AD) shows differential clinical presentation in older compared
with younger patients. Nevertheless, changes in the AD molecular profile with age are …
with younger patients. Nevertheless, changes in the AD molecular profile with age are …
Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations
PM Brunner, A Israel, N Zhang, A Leonard… - Journal of Allergy and …, 2018 - Elsevier
Background Although atopic dermatitis (AD) often starts in early childhood, detailed tissue
profiling of early-onset AD in children is lacking, hindering therapeutic development for this …
profiling of early-onset AD in children is lacking, hindering therapeutic development for this …
Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities
H He, E Del Duca, A Diaz, HJ Kim… - Journal of Allergy and …, 2021 - Elsevier
Background Molecular studies in atopic dermatitis (AD) are largely restricted to patients with
moderate-to-severe disease. Objective Our aim was to evaluate skin and blood …
moderate-to-severe disease. Objective Our aim was to evaluate skin and blood …
Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients
Background Atopic dermatitis (AD) predominantly affects young children, but our
understanding of AD pathogenesis is based on skin and blood samples from long-standing …
understanding of AD pathogenesis is based on skin and blood samples from long-standing …
Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation
RD Sanyal, AB Pavel, J Glickman, TC Chan… - Annals of Allergy …, 2019 - Elsevier
Abstract Background African Americans (AA) are disproportionately impacted by atopic
dermatitis (AD), with increased prevalence and therapeutic challenges unique to this …
dermatitis (AD), with increased prevalence and therapeutic challenges unique to this …
Phenotypical differences of childhood-and adult-onset atopic dermatitis
JI Silverberg, PP Vakharia, R Chopra, R Sacotte… - The Journal of Allergy …, 2018 - Elsevier
Background Little is known about adult-onset atopic dermatitis (AD). Objective To determine
the associations and clinical characteristics of adult-onset AD. Methods A prospective study …
the associations and clinical characteristics of adult-onset AD. Methods A prospective study …
Early immunologic changes during the onset of atopic dermatitis
PM Brunner - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Objective Atopic dermatitis (AD), which is commonly called eczema, is the most common
chronic inflammatory skin disease. The pipeline of new targeted treatments is currently …
chronic inflammatory skin disease. The pipeline of new targeted treatments is currently …
[HTML][HTML] The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic
disease with increased cardiovascular risk. To better define serum inflammatory and …
disease with increased cardiovascular risk. To better define serum inflammatory and …