Age of onset defines two distinct profiles of atopic dermatitis in adults

P Facheris, JC Da Rosa, AD Pagan, M Angelov… - Allergy, 2023 - Wiley Online Library
Background The incidence of adult‐onset atopic dermatitis (AOAD) is increasing. However,
the unique characteristics of AOAD compared to pediatric‐onset AD persisting into …

Adult-onset atopic dermatitis: presentations and progress

AR Chan, VK Sandhu, AM Drucker… - Journal of …, 2020 - journals.sagepub.com
Atopic dermatitis (AD) is a chronic skin disease characterized by barrier dysfunction and
immune dysregulation that affects approximately 20% of children and 2-5% of adults …

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis

L Zhou, A Leonard, AB Pavel, K Malik, A Raja… - Journal of Allergy and …, 2019 - Elsevier
Background Atopic dermatitis (AD) shows differential clinical presentation in older compared
with younger patients. Nevertheless, changes in the AD molecular profile with age are …

Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations

PM Brunner, A Israel, N Zhang, A Leonard… - Journal of Allergy and …, 2018 - Elsevier
Background Although atopic dermatitis (AD) often starts in early childhood, detailed tissue
profiling of early-onset AD in children is lacking, hindering therapeutic development for this …

Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities

H He, E Del Duca, A Diaz, HJ Kim… - Journal of Allergy and …, 2021 - Elsevier
Background Molecular studies in atopic dermatitis (AD) are largely restricted to patients with
moderate-to-severe disease. Objective Our aim was to evaluate skin and blood …

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients

PM Brunner, A Israel, A Leonard, AB Pavel… - Annals of Allergy …, 2019 - Elsevier
Background Atopic dermatitis (AD) predominantly affects young children, but our
understanding of AD pathogenesis is based on skin and blood samples from long-standing …

Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation

RD Sanyal, AB Pavel, J Glickman, TC Chan… - Annals of Allergy …, 2019 - Elsevier
Abstract Background African Americans (AA) are disproportionately impacted by atopic
dermatitis (AD), with increased prevalence and therapeutic challenges unique to this …

Phenotypical differences of childhood-and adult-onset atopic dermatitis

JI Silverberg, PP Vakharia, R Chopra, R Sacotte… - The Journal of Allergy …, 2018 - Elsevier
Background Little is known about adult-onset atopic dermatitis (AD). Objective To determine
the associations and clinical characteristics of adult-onset AD. Methods A prospective study …

Early immunologic changes during the onset of atopic dermatitis

PM Brunner - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Objective Atopic dermatitis (AD), which is commonly called eczema, is the most common
chronic inflammatory skin disease. The pipeline of new targeted treatments is currently …

[HTML][HTML] The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

PM Brunner, M Suárez-Fariñas, H He, K Malik… - Scientific reports, 2017 - nature.com
Beyond classic “allergic”/atopic comorbidities, atopic dermatitis (AD) emerges as systemic
disease with increased cardiovascular risk. To better define serum inflammatory and …