The clinical manifestations, molecular mechanisms and treatment of craniosynostosis

E Stanton, M Urata, JF Chen… - Disease Models & …, 2022 - journals.biologists.com
Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

Craniosynostosis: molecular pathways and future pharmacologic therapy

K Senarath-Yapa, MT Chung, A McArdle… - …, 2012 - Taylor & Francis
Craniosynostosis describes the premature fusion of one or more cranial sutures and can
lead to dramatic manifestations in terms of appearance and functional impairment …

Recent advances in craniosynostosis

E Yilmaz, E Mihci, B Nur, ÖM Alper, Ş Taçoy - Pediatric Neurology, 2019 - Elsevier
Craniosynostosis is a pathologic craniofacial disorder and is defined as the premature
fusion of one or more cranial (calvarial) sutures. Cranial sutures are fibrous joints consisting …

Genetic advances in craniosynostosis

W Lattanzi, M Barba, L Di Pietro… - American journal of …, 2017 - Wiley Online Library
Craniosynostosis, the premature ossification of one or more skull sutures, is a clinically and
genetically heterogeneous congenital anomaly affecting approximately one in 2,500 live …

Closing the gap: genetic and genomic continuum from syndromic to nonsyndromic craniosynostoses

Y Heuzé, G Holmes, I Peter, JT Richtsmeier… - … genetic medicine reports, 2014 - Springer
Craniosynostosis, a condition that includes the premature fusion of one or multiple cranial
sutures, is a relatively common birth defect in humans and the second most common …

[HTML][HTML] Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis

MA Katsianou, C Adamopoulos, H Vastardis… - BBA clinical, 2016 - Elsevier
Normal extension and skull expansion is a synchronized process that prevails along the
osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites …

A genetic-pathophysiological framework for craniosynostosis

SRF Twigg, AOM Wilkie - The American Journal of Human Genetics, 2015 - cell.com
Craniosynostosis, the premature fusion of one or more cranial sutures of the skull, provides
a paradigm for investigating the interplay of genetic and environmental factors leading to …

Evidence-based medicine: nonsyndromic craniosynostosis

Y Tahiri, SP Bartlett, MS Gilardino - Plastic and reconstructive …, 2017 - journals.lww.com
Craniosynostosis is a pathologic condition associated with the premature fusion of one or
more cranial sutures. When the cranial sutures fuse prematurely, the skull and the growing …

Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis

M Yu, L Ma, Y Yuan, X Ye, A Montagne, J He, TV Ho… - Cell, 2021 - cell.com
Craniosynostosis results from premature fusion of the cranial suture (s), which contain
mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with …

Understanding craniosynostosis as a growth disorder

K Flaherty, N Singh… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
Craniosynostosis is a condition of complex etiology that always involves the premature
fusion of one or multiple cranial sutures and includes various anomalies of the soft and hard …