Accelerating research on biological aging and mental health: Current challenges and future directions

LKM Han, JE Verhoeven, AR Tyrka… - …, 2019 - Elsevier
Aging is associated with complex biological changes that can be accelerated, slowed, or
even temporarily reversed by biological and non-biological factors. This article focuses on …

Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders

E Sibille - Dialogues in clinical neuroscience, 2013 - Taylor & Francis
The increased risk for neurodegenerative and neuropsychiatric disorders associated with
extended lifespan has long suggested mechanistic links between chronological age and …

Biological aging and the future of geriatric psychiatry

BR Rutherford, WD Taylor, PJ Brown… - … Series A: Biomedical …, 2017 - academic.oup.com
Advances in understanding the biological bases of aging have intellectually revitalized the
field of geriatric psychiatry and broadened its scope to include promoting successful aging …

[HTML][HTML] Psychological aging, depression, and well-being

M Mitina, S Young, A Zhavoronkov - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Aging is a multifactorial process, which affects the human body on every level and results in
both biological and psychological changes. Multiple studies have demonstrated that a lower …

[HTML][HTML] Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?

M Keshavarz, K Xie, K Schaaf, D Bano… - Molecular …, 2023 - nature.com
Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

[HTML][HTML] Stress-induced biological aging: A review and guide for research priorities

LR Polsky, KE Rentscher, JE Carroll - Brain, behavior, and immunity, 2022 - Elsevier
Exposure to chronic adverse conditions, and the resultant activation of the neurobiological
response cascade, has been associated with an increased risk of early onset of age-related …

The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health

CE Lyons, M Razzoli, A Bartolomucci - Neuroscience & Biobehavioral …, 2023 - Elsevier
Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

The Psychoneuroendocrinology of Aging: Anabolic and Catabolic Hormones.

ES Epel, HM Burke, OM Wolkowitz - 2007 - psycnet.apa.org
As the American population ages, the number of Americans with some form of age-related
disease (eg, heart disease, diabetes, cancer, Alzheimer's disease) will reach epidemic …

[HTML][HTML] Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Mental health and aging in the 2020s.

BD Carpenter, M Gatz, MA Smyer - American Psychologist, 2022 - psycnet.apa.org
The COVID-19 pandemic has brought age bias and the unmet mental health needs of older
adults into bold relief. Even before the pandemic, the psychological needs of older adults …