Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a

H Wu, Z Li, Y Yang, L Zhang, Y Yuan, Y Wang, G Li… - Cellular …, 2023 - Elsevier
Abnormal elevation of homocysteine (Hcy) level accelerates atherosclerosis through
promote macrophage inflammation, while the precise mechanisms remain to be well …

[HTML][HTML] FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE−/− mice atherosclerosis

L Xu, H Zhang, Y Wang, A Yang, X Dong, L Gu… - Laboratory …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease, and inflammation plays a critical
role in its formation and progression. Elevated serum homocysteine (Hcy) is an independent …

[HTML][HTML] TGFB3-AS1 promotes Hcy-induced inflammation of macrophages via inhibiting the maturity of miR-144 and upregulating Rap1a

H Zhang, Y Hao, A Yang, L Xie, N Ding, L Xu… - … Therapy-Nucleic Acids, 2021 - cell.com
It has been demonstrated that homocysteine (Hcy) can cause inflammatory diseases. Long
noncoding RNAs (lncRNA) and microRNAs (miRNAs) are involved in this biological …

Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells

X Pang, J Liu, J Zhao, J Mao, X Zhang, L Feng, C Han… - Atherosclerosis, 2014 - Elsevier
Abstract Objective Homocysteine (Hcy) is known as an independent risk factor for
atherosclerosis. C-reactive protein (CRP) directly participates in initiation and progression of …

miR‐195‐3p alleviates homocysteine‐mediated atherosclerosis by targeting IL‐31 through its epigenetics modifications

J Xiong, F Ma, N Ding, L Xu, S Ma, A Yang, Y Hao… - Aging cell, 2021 - Wiley Online Library
Atherosclerosis is a serious age‐related disease, which has a tremendous impact on health
care globally. Macrophage inflammation is crucial for the initiation and progression of …

[HTML][HTML] Homocysteine impairs endothelial cell barrier function and angiogenic potential via the progranulin/EphA2 pathway

D Tian, Q Qin, M Li, X Li, Q Xu, Q Lv - Frontiers in Pharmacology, 2021 - frontiersin.org
Hyperhomocysteinemia is a well-recognized independent risk factor for cardiovascular
disease. To date, the mechanism of pathological plasma homocysteine (Hcy) level elevation …

[HTML][HTML] Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial …

H Hu, C Wang, Y Jin, Q Meng, Q Liu, Z Liu, K Liu, X Liu… - Inflammation, 2019 - Springer
Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for
atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an …

[HTML][HTML] SNF5 promotes IL-1β expression via H3K4me1 in atherosclerosis induced by homocysteine

L Xie, N Ding, H Zhang, K Liu, J Xiong, S Ma… - … International Journal of …, 2021 - Elsevier
Homocysteine (Hcy) is a strong and independent risk factor of atherosclerosis. It can
accelerate atherosclerosis through increased production of inflammatory factors, especially …

Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways

YS Lee, SJ Lee, KW Seo, JU Bae, SY Park… - Free radical …, 2013 - Taylor & Francis
Homocysteine (Hcy) at elevated levels is a putative risk factor for many cardiovascular
disorders including atherosclerosis. In the present study, we investigated the effect of Hcy on …

[HTML][HTML] Homocysteine induces inflammatory transcriptional signaling in monocytes

S Meng, S Ciment, M Jan, T Tran, H Pham… - … in bioscience: a …, 2013 - ncbi.nlm.nih.gov
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease.
This study is to investigate transcriptional mechanism underlying homocysteine (Hcy) …