Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …

Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Targeting toll-like receptors for cancer therapy

MJ Braunstein, J Kucharczyk, S Adams - Targeted oncology, 2018 - Springer
The immune system encompasses a broad array of defense mechanisms against foreign
threats, including invading pathogens and transformed neoplastic cells. Toll-like receptors …

[HTML][HTML] The critical role of Toll-like receptor-mediated signaling in cancer immunotherapy

X Chen, Y Zhang, Y Fu - Medicine in Drug Discovery, 2022 - Elsevier
Toll-like receptors (TLR) play a dual regulatory role in the tumor microenvironment (TME).
TLR agonists (TLRa) elicit both innate and adaptive immune responses to achieve anti …

Trial Watch: Experimental Toll-like receptor agonists for cancer therapy

L Galluzzi, E Vacchelli, A Eggermont… - …, 2012 - Taylor & Francis
Toll-like receptors (TLRs) are prototypic pattern recognition receptors (PRRs) best known for
their ability to activate the innate immune system in response to conserved microbial …

Application potential of toll-like receptors in cancer immunotherapy: Systematic review

M Shi, X Chen, K Ye, Y Yao, Y Li - Medicine, 2016 - journals.lww.com
Abstract Toll-like receptors (TLRs), as the most important pattern recognition receptors in
innate immunity, play a pivotal role in inducing immune response through recognition of …

Toll-like receptors from the perspective of cancer treatment

N Javaid, S Choi - Cancers, 2020 - mdpi.com
Toll-like receptors (TLRs) represent a family of pattern recognition receptors that recognize
certain pathogen-associated molecular patterns and damage-associated molecular …

Toll‐like receptors (TLRs) in cancer; with an extensive focus on TLR agonists and antagonists

A Keshavarz, A Pourbagheri‐Sigaroodi, P Zafari… - IUBMB …, 2021 - Wiley Online Library
At the forefront of the battle against pathogens or any endogenously released molecules, toll‐
like receptors (TLRs) play an important role as the most noble pattern recognition receptors …

[PDF][PDF] Targeting Toll-like receptors against cancer

B Du, QL Jiang, J Cleveland… - Journal of Cancer …, 2016 - pdfs.semanticscholar.org
The discovery of Toll-like receptors (TLRs) about 20 years ago was a remarkable
achievement not only in the field of immunology but also in the field of medicine. The TLRs …

Toll-like receptors as a therapeutic target in cancer, infections and inflammatory diseases

L Flórez-Álvarez, L Ruiz-Perez, N Taborda… - …, 2020 - Taylor & Francis
Toll-like receptors (TLRs) are widely expressed pattern recognition receptors that bind to
conserved molecular patterns expressed by pathogens and damaged cells. After …