Human inborn errors of IFN-γ immunity underlie mycobacterial diseases. We describe
patients with Mycobacterium bovis (BCG) disease who are homozygous for loss-of-function …

The pathophysiology of adverse events following programmed cell death protein 1 (PD-1)
blockade, including tuberculosis (TB) and autoimmunity, remains poorly characterized. We …

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of IFN-
γ immunity. Affected patients are highly and selectively susceptible to weakly virulent …

Isoprenoids are vital for all organisms, in which they maintain membrane stability and
support core functions such as respiration. IspH, an enzyme in the methyl erythritol …

Human inborn errors of IFN-γ underlie mycobacterial disease, due to insufficient IFN-γ
production by lymphoid cells, impaired myeloid cell responses to this cytokine, or both. We …

Summary The type-1 cytokine (interleukin 12, interleukin 23, interferon γ, interleukin 17)
signalling pathway is triggered during infection by activation of phagocyte-expressed pattern …

Programmed cell death 1 (PD-1) is an inhibitory coreceptor on immune cells and is essential
for self-tolerance because mice genetically lacking PD-1 (PD-1−/−) develop spontaneous …

B cell development requires tight regulation to allow for the generation of a diverse
repertoire while preventing the development of autoreactive cells. We report, using N-ethyl …

Mycobacterium tuberculosis (Mtb) exposure drives antibody responses, but whether patients
with active tuberculosis elicit protective antibodies, and against which antigens, is still …

Germline mutations in CYBB, the human gene encoding the gp91phox subunit of the
phagocyte NADPH oxidase, impair the respiratory burst of all types of phagocytes and result …