The mammalian skull vault is constructed principally from five bones: the paired frontals and
parietals, and the unpaired interparietal. These bones abut at sutures, where most growth of …

Enlargement of the skull vault occurs by appositional growth at the fibrous joints between the
bones, termed cranial sutures. Relatively little is known about the developmental biology of …

The skull vault is a complex, exquisitely patterned structure that plays a variety of key roles in
vertebrate life, ranging from the acquisition of food to the support of the sense organs for …

✓ Skull growth after single suture closure was described in 1851 by Virchow, who noted that
growth in the plane perpendicular to a fused suture was restricted. However, this …

Intramembranous bone growth is achieved through bone formation within a periosteum or
by bone formation at sutures. Sutures are formed during embryonic development at the sites …

Craniosynostosis is a condition of complex etiology that always involves the premature
fusion of one or multiple cranial sutures and includes various anomalies of the soft and hard …

Skull growth after premature fusion of a single suture was described by Virchow in 1851. He
observed that growth was restricted in a plane perpendicular to a fused suture. However, he …

Understanding the development of a skull deformity requires an understanding of the normal
morphogenesis of the cranium. Craniosynostosis is the premature, pathologic ossification of …

The development of calvarial bones is tightly co-ordinated with the growth of the brain and
needs harmonious interactions between different tissues within the calvarial sutures …

The term craniosynostosis was first used in 1830 by Otto to describe the premature fusion of
cranial sutures (Otto, 1830). Since this first identification of craniosynostosis as a distinct …