Objective.—To assess whether an association exists between moderate alcohol
consumption and plasma concentration of endogenous tissue-type plasminogen activator (t …

Few haematological or lipid risk factors have been identified for stroke, by contrast with
coronary heart disease. To find out whether a marker of endogenous fibrinolytic function …

Confluent cultures of cloned bovine endothelial cells, which were derived from large
vessels, produced and secreted plasminogen activator (PA) at constant rates. Exposure of …

Endogenous tissue-type plasminogen activator (tPA) has been hypothesised to be a marker
of baseline fibrinolytic capacity. We therefore tested whether tPA antigen is associated with …

Light-to-moderate alcohol intake is associated with a reduced incidence of ischaemic
cardiovascular events, whilst heavy alcohol intake can predispose individuals to stroke …

Background—Moderate alcohol consumers have lower rates of cardiovascular disease than
abstainers. One proposed mechanism is a beneficial effect on hemostatic parameters, but …

Background—Effective endogenous fibrinolysis requires rapid release of tissue
plasminogen activator (tPA) from the vascular endothelium. Smoking is a known risk factor …

BACKGROUND Although isolated abnormalities of plasminogen activation and inhibition
have been reported among selected patients with venous thrombosis, it is unclear whether …

Increased levels of an endogenous inhibitor of tissueplasminogen activator (t-PA) have
been thought to relate to the genesis of acute myocardial ischemia. To examine the role of …

In contrast to a reduced risk of coronary heart disease (CHD) with light to moderate alcohol
consumption, heavy alcohol intake and binge drinking are associated with increased …