BACKGROUND Coagulopathy and inflammation induced by hemorrhagic shock and
traumatic injury are associated with increased mortality and morbidity. Vitamin C (VitC) is an …

Trauma, burns, and sepsis evoke a systemic inflammatory response that lead to increased
permeability and fluid extravasation. The result is a cascade of cytokines causing changes in …

Fluid resuscitation to maintain adequate tissue perfusion while reducing edema in the
severely burned patient remains a challenge. Recent studies suggest that reactive oxygen …

BACKGROUND Compared with lyophilized plasma (LP) buffered with other acids, LP with
ascorbic acid (AA) attenuates systemic inflammation and DNA damage in a combat relevant …

Background Fluid resuscitation plays a prominent role in stabilizing trauma patients with
hemorrhagic shock yet there remains uncertainty with regard to optimal administration time …

Background: Activated factor VII catalyzes the activation of clotting factors IX and X within the
clotting cascade, and has been used clinically to decrease bleeding in patients with …

BACKGROUND Uncontrolled bleeding is the leading cause of potentially preventable
deaths among trauma patients. Tissue injury and shock result in trauma-induced …

Abstract Background Vitamin C (VitC) has recently been shown to exert beneficial effects,
including protecting organ function and inhibiting inflammation, in various critical care …

In Europe, each day over 1,000 patients have a cardiac arrest [1]. Only half of these patients
arrive at the hospital alive. Of these survivors, 50% will still die or remain severely disabled …

BACKGROUND Acute traumatic coagulopathy (ATC) occurs after severe injury and shock
and is associated with increased bleeding, morbidity, and mortality. The effects of ATC and …