Solid tumors are constituted of a variety of cellular components, including bona fide
malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor …

In the recent years, breakthrough advances in the characterization of the tumor-infiltrating
immune cells and in the understanding of their influence on tumor invasion and metastasis …

The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been a longstanding
topic of debate. In cases where TILs have improved patient outcome, T lymphocytes are …

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can
provide important prognostic information in diverse solid tumor types, and may also be of …

Leukocyte infiltrates into or around tumor cell nests are found in the context of
protumorigenic inflammation and anticancer immunosurveillance. Hence, the detailed …

Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity.
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …

As epithelial tumors grow from single cells to a malignant mass of invasive tissue, they must
exploit the innate inflammatory response, while evading the adaptive immune system …

Background: Tumour-infiltrating lymphocytes (TILs) are often found in tumours, presumably
reflecting an immune response against the tumour. We carried out a systematic review and …

In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in
different clinical studies. Currently, immunotherapy was clinically validated as effective …

Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …