This review describes the characteristics of a number of pathologies, which are considered
from the point of view of chronobiology, that is, the way in which biological processes are …

Introduction Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a
number of drugs and affects their therapeutic efficacy and toxicity depending on the time of …

The importance of circadian rhythm dysfunctions in the pathophysiology of neurological
diseases has been highlighted recently. Chronopharmacology principles imply that tailoring …

Extensive research into circadian rhythms and their influence on biological systems has
given rise to the science of chronobiology and subsequently chronotherapy, the science of …

The last four decades have witnessed considerable advances in our knowledge of the
pharmacology of sleep. Both basic and clinical pharmacology have made major …

Circadian rhythms are a collection of endogenously driven biochemical, physiological, and
behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues …

Background Chronotherapy involves altering the timing of medication administration to
improve the overall control of a disease and to minimise treatment side-effects, and is an …

PREVIEW Although many aspects of human biology display circadian rhythms, only recently
have researchers discovered that diseases also have predictable cyclic rhythms and that the …

Chronotherapeutics is a treatment method in which in vivo drug availability is timed in
relation to repetitive rhythms of drug-related biologic phenomena to produce maximum …

This review is concerned with circadian (∼ 24 h) aspects of chronobiology, and how they
relate to sleep disorders medicine. We begin with an introduction to the key concepts and …