Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis

S Li, Y Wang, Z Wang, L Chen, B Zuo, C Liu… - Stem Cell Research & …, 2021 - Springer
Background The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose
tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the …

[HTML][HTML] GDNF enhances the anti-inflammatory effect of human adipose-derived mesenchymal stem cell-based therapy in renal interstitial fibrosis

Z Wang, S Li, Y Wang, X Zhang, L Chen, D Sun - Stem cell research, 2019 - Elsevier
Adipose-derived mesenchymal stem cells (AMSCs) are a type of adult stem cell from the
mesoderm with the capacity to migrate and differentiate into other cell lineages. As a …

[HTML][HTML] Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating …

L Chen, Y Wang, S Li, B Zuo, X Zhang, F Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) have emerged as ideal cell-based therapeutic candidates
for the structural and functional restoration of the diseased kidney. Glial cell line-derived …

Adipose-derived stem cells ameliorate renal interstitial fibrosis through inhibition of EMT and inflammatory response via TGF-β1 signaling pathway

Y Song, C Peng, S Lv, J Cheng, S Liu, Q Wen… - International …, 2017 - Elsevier
Adipose-derived stem cells (ADSCs) have been successfully used to treat acute kidney
injury or acute renal failure. However, the effect of ADSCs on treating renal interstitial fibrosis …

Adipose-derived mesenchymal stem cells: a new tool for the treatment of renal fibrosis

Z Wang, D Sun - Stem Cells and Development, 2018 - liebertpub.com
As chronic kidney disease progresses, kidney tissue inevitably undergoes cell loss,
accumulation of extracellular matrix, and kidney tissue fibrosis, eventually leading to end …

Adipose tissue-derived stem cell treatment prevents renal disease progression

C Donizetti-Oliveira, P Semedo… - Cell …, 2012 - journals.sagepub.com
Adipose tissue-derived stem cells (ASCs) are an attractive source of stem cells with
regenerative properties that are similar to those of bone marrow stem cells. Here, we …

Human adipose derived stem cells regress fibrosis in a chronic renal fibrotic model induced by adenine

JJ Rivera-Valdés, J Garcia-Banuelos… - PLoS …, 2017 - journals.plos.org
Background and aims ADSCs transplantation had been shown in some experimental
models of kidney damage that it improves kidney function and reduces fibrosis. In this study …

Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat

H Tang, P Zhang, L Zeng, Y Zhao, L Xie… - Stem Cell Research & …, 2021 - Springer
Background Tubulointerstitial fibrosis (TIF) is one of the main pathological features of
various progressive renal damages and chronic kidney diseases. Mesenchymal stromal …

Possible mechanisms for the renoprotective action of adipose-derived mesenchymal stem cells with CD44-targeted hyaluronic acid against renal ischemia

A Awadalla, AM Hussein, M Ali, N Barakat, ET Hamam… - Life Sciences, 2021 - Elsevier
The present study aimed to investigate the invitro preconditioning of adipose-derived
mesenchymal stem cells (ADMSCs) with CD44-targeted hyalournic acid (HA) on ischemic …

[HTML][HTML] Mesenchymal stem cells ameliorate fibrosis by enhancing autophagy via inhibiting galectin-3/Akt/mTOR pathway and by alleviating the EMT via inhibiting …

Y Zhao, C Guo, L Zeng, J Li, X Liu, Y Wang… - Int J Stem …, 2023 - synapse.koreamed.org
Methods and Results Galectin-3 knockdown (Gal-3 KD) and overexpression (Gal-3 OE)
lentiviral vectors were established and transfected into NRK-52E. NRK-52E fibrosis model …