Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience
Mental health disorders often arise as a combination of environmental and genetic factors.
The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key …
The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
[HTML][HTML] Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
[HTML][HTML] Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Identification and characterisation of novel targets for treatment is a priority in the field of
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …
[HTML][HTML] Expression and Regulation of the Fkbp5 Gene in the Adult Mouse Brain
SH Scharf, C Liebl, EB Binder, MV Schmidt, MB Müller - PloS one, 2011 - journals.plos.org
Background Chronic stress has been found to be a major risk factor for various human
pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly …
pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly …
[HTML][HTML] Depletion of FKBP51 in female mice shapes HPA axis activity
L Hoeijmakers, D Harbich, B Schmid, PJ Lucassen… - PLoS …, 2014 - journals.plos.org
Psychiatric disorders such as depressive disorders and posttraumatic stress disorder are a
major disease burden worldwide and have a higher incidence in women than in men …
major disease burden worldwide and have a higher incidence in women than in men …
The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance
JC O'Leary III, B Zhang, J Koren III… - CNS & Neurological …, 2013 - ingentaconnect.com
Research on the FKBP5 gene and FKBP51 protein has more than doubled since the
discovery that polymorphisms in this gene could alter treatment outcomes and depressive …
discovery that polymorphisms in this gene could alter treatment outcomes and depressive …
[HTML][HTML] Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene
combine with traumatic events to increase risk for post-traumatic stress and major …
combine with traumatic events to increase risk for post-traumatic stress and major …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …
development and function of the human brain and, ultimately, the risk of psychiatric …