Purpose: Osteosarcoma (OS) is one of the most common primary bone tumors. Direct
pathogenesis remains unknown, however, genes' mutations are proven to participate in the …

Osteosarcomas are genetically complex tumours for which the cell of origin and the
molecular pathogenesis are still poorly understood. Despite intensive multimodal treatment …

Experimental Study of Somatic Variants of Osteosarcoma by Whole-Exome Sequencing -
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Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent
progress made in molecular genetic studies of osteosarcoma has changed our view on the …

Osteosarcomas (OSs) are functionally defined tumors, and the function may be affected by
two endogenous factors: cell-of-origin and genetic alterations. Since the identification of …

Osteosarcoma is one of the most prevalent primary bone tumors. The pathogenesis and
molecular development of this tumor remains elusive. The prognosis is unfavorable due to …

Introduction: Genetic characterization of osteosarcoma has evolved during the last decade,
thanks to the integrated application of conventional and new candidate-driven and genome …

Background: Osteosarcoma has been recently redefined as a differentiation disease and its
investigation is hampered by broad and complex genetic alterations. Gene expression …

Objective The limited understanding of correlation between genomic features and biological
behaviors has impeded the therapeutic breakthrough in osteosarcoma (OS). This study …

Illustrating the molecular consequence of deleterious mutations is essential for bridging the
gap between genotype and phenotype. In the cancer field, differential expression of the two …