Astrocytes are important for information processing in the brain and they achieve this by fine‐
tuning neuronal communication via continuous uptake and release of biochemical …

A defining pathophysiological hallmark of Alzheimer's disease (AD) is the amyloid plaque;
an extracellular deposit of aggregated fibrillar Aβ1-42 peptides. Amyloid plaques are hard …

Microglia are the brain's resident immune cells, performing surveillance to promote
homeostasis and healthy functioning. While microglial chemical signaling is well-studied …

Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular
mechanical cues to intracellular molecular signaling cascades through a process termed …

Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and
mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the …

Background Microglia are the endogenous immune cells of the brain and act as sensors of
pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's …

Mechanical properties of the brain such as intracranial pressure or stiffness of the matrix
play an important role in the brain's normal physiology and pathophysiology. The physical …

Adult brain activities are generally believed to be dominated by chemical and electrical
transduction mechanisms. However, the importance of mechanotransduction mediated by …

The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …

Piezo1 is a mechanically-gated calcium channel. Recent studies have shown that Piezo1, a
mechanically-gated calcium channel, can attenuate both psychosine-and …