The nose: gatekeeper and trigger of bronchial disease.

G Hens, PW Hellings - Rhinology, 2006 - europepmc.org
The nose is strategically placed at the entrance of the airway. Nose breathing takes place
under physiologic circumstances and protects the lower airways from exposure to …

The relationship between asthma and allergic rhinitis: exploring the basis for a common pathophysiology

AM Vignola, P Chanez… - Clinical & Experimental …, 2003 - Wiley Online Library
Most patients with asthma also have rhinitis, and the same inflammatory cells and
mechanisms are present in bronchial and nasal mucosa, thus leading to the concept of 'one …

A chest physician's guide to mechanisms of sinonasal disease

V Hox, T Maes, W Huvenne, C Van Drunen… - Thorax, 2015 - thorax.bmj.com
The upper and lower airways are closely linked from an anatomical, histological and
immunological point of view, with inflammation in one part of the airways influencing the …

Global airway disease beyond allergy

PW Hellings, EP Prokopakis - Current allergy and asthma reports, 2010 - Springer
Besides the anatomic continuity of the upper and lower airways, inflammation in one part of
the airway influences the homeostasis of the other. The mechanisms underlying this …

The link between allergic rhinitis and asthma: the united airways disease

E Compalati, E Ridolo, G Passalacqua… - Expert review of …, 2010 - Taylor & Francis
Rhinitis and asthma are often associated and the two disorders interact at various levels.
Rhinitis typically precedes the development of asthma and can contribute to unsatisfactory …

Impact of rhinitis on airway inflammation: biological and therapeutic implications

G Passalacqua, GW Canonica - Respiratory Research, 2001 - Springer
There is increasing evidence for a close link between the upper and the lower respiratory
tracts and the fact that rhinitis has an important impact on asthma. Several clinical and …

United airway disease: current perspectives

P Giavina-Bianchi, P Takejima, J Kalil… - Journal of asthma and …, 2016 - Taylor & Francis
Upper and lower airways are considered a unified morphological and functional unit, and
the connection existing between them has been observed for many years, both in health and …

Allergic rhinitis and asthma: the link further unraveled

GJ Braunstahl, PW Hellings - Current opinion in pulmonary …, 2003 - journals.lww.com
Allergic asthma and rhinitis are manifestations of the atopic syndrome. Although the
diseases commonly occur together, it is still unclear why some allergic patients develop only …

United airways concept: what does it teach us about systemic inflammation in airways disease?

GJ Braunstahl - Proceedings of the American Thoracic Society, 2009 - atsjournals.org
Allergic asthma and rhinitis are manifestations of the atopic syndrome and often coexist. It
has been demonstrated that allergic rhinitis is a strong risk factor for the onset of asthma in …

Allergic rhinitis: past, present and the future

RJ Salib, A Drake‐Lee… - Clinical Otolaryngology & …, 2003 - Wiley Online Library
Allergic rhinitis: past, present and the future Allergic rhinitis represents a global health issue
affecting between 10% to 25% of the world population, with increasing prevalence over the …