Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Y Meng, KA Davies, C Fitzgibbon, SN Young… - Nature …, 2021 - nature.com
The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …
[HTML][HTML] The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
Mixed lineage kinase domain-like (MLKL) is a component of the" necrosome," the
multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by …
multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by …
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
AL Samson, C Fitzgibbon, KM Patel… - Cell Death & …, 2021 - nature.com
Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human
pathologies. The pathway is executed by a core machinery comprising the RIPK1 and …
pathologies. The pathway is executed by a core machinery comprising the RIPK1 and …
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
KA Davies, C Fitzgibbon, SN Young, SE Garnish… - Nature …, 2020 - nature.com
The MLKL pseudokinase is the terminal effector in the necroptosis cell death pathway.
Phosphorylation by its upstream regulator, RIPK3, triggers MLKL's conversion from a …
Phosphorylation by its upstream regulator, RIPK3, triggers MLKL's conversion from a …
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
EJ Petrie, RW Birkinshaw, A Koide… - Proceedings of the …, 2020 - National Acad Sciences
The necroptosis cell death pathway has been implicated in host defense and in the
pathology of inflammatory diseases. While phosphorylation of the necroptotic effector …
pathology of inflammatory diseases. While phosphorylation of the necroptotic effector …
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
The pseudokinase MLKL (mixed lineage kinase domain-like), has recently emerged as a
critical component of the necroptosis cell death pathway. Although it is clear that …
critical component of the necroptosis cell death pathway. Although it is clear that …
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Necroptotic cell death is mediated by the most terminal known effector of the pathway,
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …
[HTML][HTML] Post-translational control of RIPK3 and MLKL mediated necroptotic cell death
Several programmed lytic and necrotic-like cell death mechanisms have now been
uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3) …
uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3) …
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …