Acute pancreatitis is a disease associated with suffering and high lethality. Although the
disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar …

Inhibition of phospholipase A2 (PLA2) has long been considered for treating various
diseases associated with an elevated PLA2 activity. However, safe and effective PLA2 …

Ulinastatin is commonly used in the clinic to treat acute pancreatitis (AP), but its therapeutic
effect was limited by the presence of the blood–pancreas barrier (BPB) and low specificity …

Abstract Background and Aims: Inflammatory mediator S100A9 is dramatically elevated in
ulcerative colitis and correlates with disease severity. S100A9 is a potential molecule to …

Inflammation is a key homeostatic process involved in the body's response to a multitude of
disease states including infection, autoimmune disorders, cancer, and other chronic …

Chronic pancreatitis (CP) is a disease that imposes great suffering on people's lives with
symptoms such as chronic abdominal pain, diabetes, impaired digestion, high risk of …

Sepsis, resulting from uncontrolled inflammatory responses to bacterial infections, continues
to cause high morbidity and mortality worldwide. Currently, effective sepsis treatments are …

Dysfunction in the macrophage lysosomal system including reduced acidity and diminished
degradative capacity is a hallmark of atherosclerosis, leading to blunted clearance of excess …

Background Impaired or hyperactive pancreas regeneration after injury would cause
exocrine insufficiency or recurrent/chronic pancreatitis and potentially carcinogenesis …

Biomaterials-based nanovaccines, such as those made of poly (lactic-co-glycolic
acid)(PLGA), can induce stronger immunity than soluble antigens in healthy wild-type …