The use of blood spot collection cards was investigated as a means of obtaining small
volume samples for the analysis of therapeutic drugs for the purpose of neonatal …

A new simple, sensitive and selective liquid chromatography coupled with mass
spectrometry (LC/MS) method for quantification of captopril after precolumn derivatization …

The ethical and practical issues of obtaining a blood sample pose a significant challenge to
performing pharmacokinetic studies in children, infants and neonates. Dried blood spot …

Captopril is commonly used in pediatric patients suffered from hypertension or heart failure.
The most convenient and easiest dosage form for administration to these patients is liquid …

A specific hyphenated high performance liquid chromatography–mass spectrometric (LC–
MS/MS) assay was developed for the determination of captopril in plasma. The drug was …

Background: A free urinary captopril is measured indirectly employing the iodine-azide
reaction in post-column mode. The pre-clean-up and/or derivatization step is needless, so …

A rapid, simple and sensitive assay was developed for determination of captopril in human
serum. We employed silica gel cartridge for efficient extraction of captopril adduct from …

Both derivatization of free captopril in human plasma samples using monobromobimane as
fluorescent label and the corresponding HPLC-fluorescence detection (FLD) method were …

This study describes the development and comparison of two HPLC methods for the
analysis of the antihypertensive drug captopril. The first method is based on a precolumn …

Early in the discovery stage, the measurement of drug candidates in biological fluids as a
function time provides important information used in decision making for lead optimization …