Computational Modeling of IN-CTD/TAR Complex to Elucidate Additional Strategies to Inhibit HIV-1 Replication
L Qiu, S Bhutoria, GV Kalpana, X Zou - Virus-Host Interactions: Methods …, 2022 - Springer
Abstract HIV-1 integrase (IN) is a key enzyme that is essential for mediating the insertion of
retroviral DNA into the host chromosome. IN also exhibits additional functions which are not …
retroviral DNA into the host chromosome. IN also exhibits additional functions which are not …
Protein–Protein and Protein–RNA Interaction Assays to Determine Similarity of INI1/SMARCB1 and TAR RNA in Binding to HIV-1 Integrase
GV Kalpana - Virus-Host Interactions: Methods and Protocols, 2022 - Springer
INI1/SMARCB1 is a host protein that interacts with HIV-1 integrase (IN) and influences
multiple stages of viral replication. IN is a viral enzyme responsible for integration, and it also …
multiple stages of viral replication. IN is a viral enzyme responsible for integration, and it also …
[HTML][HTML] The HIV-1 integrase C-terminal domain induces TAR RNA structural changes promoting Tat binding
Recent evidence indicates that the HIV-1 Integrase (IN) binds the viral genomic RNA
(gRNA), playing a critical role in the morphogenesis of the viral particle and in the stability of …
(gRNA), playing a critical role in the morphogenesis of the viral particle and in the stability of …
[PDF][PDF] Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to TRN-SR2
S De Houwer, J Demeulemeester, W Thys… - J Biol …, 2012 - researchgate.net
Background: The molecular details of the TRNSR2/HIV-1 IN interaction are not known.
Results: Crucial amino acids in IN for the interaction with TRN-SR2 are located in the CTD …
Results: Crucial amino acids in IN for the interaction with TRN-SR2 are located in the CTD …
[HTML][HTML] INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
U Dixit, S Bhutoria, X Wu, L Qiu, M Spira… - Nature …, 2021 - nature.com
Abstract INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits
multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and …
multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and …
Molecular mechanism of HIV‐1 integrase–vDNA interactions and strand transfer inhibitor action: A molecular modeling perspective
W Xue, H Liu, X Yao - Journal of computational chemistry, 2012 - Wiley Online Library
Human immunodeficiency virus type 1 (HIV‐1) integrase (IN) is an essential enzyme for
splicing a viral DNA (vDNA) replica of its genome into host cell chromosomal DNA (hDNA) …
splicing a viral DNA (vDNA) replica of its genome into host cell chromosomal DNA (hDNA) …
Interaction between reverse transcriptase and integrase is required for reverse transcription during HIV-1 replication
SS Tekeste, TA Wilkinson, EM Weiner, X Xu… - Journal of …, 2015 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) replication requires reverse transcription of its
RNA genome into a double-stranded cDNA copy, which is then integrated into the host cell …
RNA genome into a double-stranded cDNA copy, which is then integrated into the host cell …
HIV-1 integrase binding to its cellular partners: A perspective from computational biology
V Cam Quy, V Carnevale, L Manganaro… - Current …, 2014 - ingentaconnect.com
Viral DNA integration into the infected cell genome is an essential step in the HIV-1 life
cycle. Hence, the viral integrase enzyme has become an important target for antiviral …
cycle. Hence, the viral integrase enzyme has become an important target for antiviral …
Defining the DNA substrate binding sites on HIV-1 integrase
A tetramer model for human immunodeficiency virus type 1 (HIV-1) integrase (IN) with DNA
representing long terminal repeat (LTR) termini was previously assembled to predict the IN …
representing long terminal repeat (LTR) termini was previously assembled to predict the IN …
[HTML][HTML] Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA
S Winans, SP Goff - PLoS Pathogens, 2020 - journals.plos.org
The central function of the retroviral integrase protein (IN) is to catalyze the integration of
viral DNA into the host genome to form the provirus. The IN protein has also been reported …
viral DNA into the host genome to form the provirus. The IN protein has also been reported …