Cavernous nerve injury by radiation therapy may potentiate erectile dysfunction in rats

J Mahmood, CQ Connors, AA Alexander… - International Journal of …, 2017 - Elsevier
Purpose/Objectives Radiation-induced erectile-dysfunction (RiED) is one of the most
common side effects of radiation therapy (RT) and significantly reduces the quality of life …

Prostate-confined radiation decreased pelvic ganglia neuronal survival and outgrowth

SA Powers, MR Odom, ES Pak… - The Journal of …, 2019 - academic.oup.com
Background Erectile dysfunction (ED) is common following radiation therapy (RT) for
prostate cancer. Although the cause of RT-induced ED is unknown, damage to both the …

Pudendal nerve and internal pudendal artery damage may contribute to radiation-induced erectile dysfunction

MW Nolan, AJ Marolf, EJ Ehrhart, S Rao… - International Journal of …, 2015 - Elsevier
Purpose/Objectives Erectile dysfunction is common after radiation therapy for prostate
cancer; yet, the etiopathology of radiation-induced erectile dysfunction (RI-ED) remains …

Radiation‐induced erectile dysfunction using prostate‐confined modern radiotherapy in a rat model

M Kimura, H Yan, Z Rabbani, T Satoh… - The journal of sexual …, 2011 - academic.oup.com
Introduction The mechanisms of radiation‐induced erectile dysfunction (ED) are unclear, as
clinical studies are limited, and previous animal models were based on wide‐field …

[HTML][HTML] Radiation-induced erectile dysfunction: Recent advances and future directions

J Mahmood, AA Shamah, TM Creed, R Pavlovic… - Advances in radiation …, 2016 - Elsevier
Prostate cancer is one of the most prevalent cancers and the second leading cause of
cancer-related deaths in men in the United States. A large number of patients undergo …

Role of oxidative stress in a rat model of radiation-induced erectile dysfunction

M Kimura, ZN Rabbani, AR Zodda… - The journal of sexual …, 2012 - academic.oup.com
Introduction Chronic oxidative stress is one of the major factors playing an important role in
radiation-induced normal tissue injury. However, the role of oxidative stress in radiation …

RhoA/ROCK pathway inhibitor ameliorates erectile dysfunction induced by radiation therapy in rats

J Mahmood, R Pandita, A Zhang, S Kamlapurkar… - Radiotherapy and …, 2020 - Elsevier
Abstract Objectives Prostate cancer (PCa) treatment with radiation therapy (RT) has an
excellent cure rate. However, Radiation-induced Erectile Dysfunction (RiED) is a common …

Erectile dysfunction after radiotherapy for prostate cancer and radiation dose to the penile structures: a critical review

GJ van der Wielen, JP Mulhall, L Incrocci - Radiotherapy and Oncology, 2007 - Elsevier
Erectile dysfunction (ED) is a common sequela after external beam radiotherapy and
brachytherapy for prostate cancer. There are several structures in the vicinity of the prostate …

Electrocautery‐induced cavernous nerve injury in rats that mimics radical prostatectomy in humans

LJ Song, JQ Zhu, MK Xie, YC Wang, HB Li… - BJU …, 2014 - Wiley Online Library
Objective To investigate the early and delayed effects of cavernous nerve electrocautery
injury (CNEI) in a rat model, with the expectation that this model could be used to test …

Changes in the penile arteries of the rat after fractionated irradiation of the prostate: a pilot study

GJ Van Der Wielen, M Vermeij… - The Journal of …, 2009 - academic.oup.com
Introduction External beam radiotherapy for prostate cancer leads to erectile dysfunction in
36%–43% of patients. The underlying mechanism is largely unknown, although some …