Poly (I: C) induces human lung endothelial barrier dysfunction by disrupting tight junction expression of claudin-5
LY Huang, C Stuart, K Takeda, F D'Agnillo, B Golding - PloS one, 2016 - journals.plos.org
Viral infections are often accompanied by pulmonary microvascular leakage and vascular
endothelial dysfunction via mechanisms that are not completely defined. Here, we …
endothelial dysfunction via mechanisms that are not completely defined. Here, we …
Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly (I: C) on the regulation of Toll-like receptors, adaptor …
M Ritter, D Mennerich, A Weith, P Seither - Journal of inflammation, 2005 - Springer
Background Bacterial and viral exacerbations play a crucial role in a variety of lung diseases
including COPD or asthma. Since the lung epithelium is a major source of various …
including COPD or asthma. Since the lung epithelium is a major source of various …
Double-stranded RNA attenuates the barrier function of human pulmonary artery endothelial cells
Circulating RNA may result from excessive cell damage or acute viral infection and can
interact with vascular endothelial cells. Despite the obvious clinical implications associated …
interact with vascular endothelial cells. Despite the obvious clinical implications associated …
Long-term activation of TLR3 by poly (I: C) induces inflammation and impairs lung function in mice
NC Stowell, J Seideman, HA Raymond, KA Smalley… - Respiratory …, 2009 - Springer
Background The immune mechanisms associated with infection-induced disease
exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has …
exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has …
Activation of interferon response through toll-like receptor 3 impacts viral pathogenesis and pulmonary toll-like receptor expression during respiratory syncytial virus …
MS Boukhvalova, TB Sotomayor, RC Point… - Journal of Interferon & …, 2010 - liebertpub.com
Interferon (IFN) therapy in humans often causes flu-like symptoms by an unknown
mechanism. Poly ICLC is a synthetic dsRNA and a Toll-like receptor 3 (TLR3) agonist with a …
mechanism. Poly ICLC is a synthetic dsRNA and a Toll-like receptor 3 (TLR3) agonist with a …
Toll-like receptor 3 is a therapeutic target for pulmonary hypertension
D Farkas, AAR Thompson, AR Bhagwani… - American Journal of …, 2019 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular cell
proliferation and endothelial cell apoptosis. TLR3 (Toll-like receptor 3) is a receptor for …
proliferation and endothelial cell apoptosis. TLR3 (Toll-like receptor 3) is a receptor for …
Activation of endothelial toll-like receptor 3 impairs endothelial function
S Zimmer, M Steinmetz, T Asdonk, I Motz… - Circulation …, 2011 - Am Heart Assoc
Rationale: Endothelial dysfunction and atherosclerosis are chronic inflammatory diseases
characterized by activation of the innate and acquired immune system. Specialized protein …
characterized by activation of the innate and acquired immune system. Specialized protein …
Regulation of viral infection-induced airway remodeling cytokine production by the TLR3-EGFR signaling pathway in human bronchial epithelial cells
J Jiang, Y Wang, X Tang, Y Yao… - COPD: Journal of Chronic …, 2016 - Taylor & Francis
ABSTRACT Toll-like receptor 3 (TLR3) is involved in the virus-induced pulmonary
inflammatory response, but its role in airway remodeling after viral infection is unclear. We …
inflammatory response, but its role in airway remodeling after viral infection is unclear. We …
Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown
SR Koch, H Choi, EH Mace, RJ Stark - Cell Communication and Signaling, 2019 - Springer
Background Vascular dysfunction is commonly seen during severe viral infections.
Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in …
Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in …
Preventing occludin tight-junction disruption via inhibition of microRNA-193b-5p attenuates viral load and influenza-induced lung injury
Virus-induced lung injury is associated with loss of pulmonary epithelial-endothelial tight
junction integrity. While the alveolar-capillary membrane may be an indirect target of injury …
junction integrity. While the alveolar-capillary membrane may be an indirect target of injury …