A prospective study on glioblastoma in the elderly

AA Brandes, F Vastola, U Basso, F Berti… - … Journal of the …, 2003 - Wiley Online Library
BACKGROUND Elderly patients (age> 65 years) with glioblastoma multiforme frequently are
excluded from clinical studies, and prospective trials for patients with this age group do not …

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients

G Minniti, V De Sanctis, R Muni, F Filippone… - Journal of neuro …, 2008 - Springer
Objectives The optimal treatment for elderly patients (age> 70 years) with glioblastoma
remains controversial. We conducted a prospective trial in 32 consecutive elderly patients …

[HTML][HTML] Short-course radiation plus temozolomide in elderly patients with glioblastoma

JR Perry, N Laperriere, CJ O'Callaghan… - … England Journal of …, 2017 - Mass Medical Soc
Background Glioblastoma is associated with a poor prognosis in the elderly. Survival has
been shown to increase among patients 70 years of age or younger when temozolomide …

Glioblastoma in elderly patients: safety and efficacy of adjuvant radiotherapy with concomitant temozolomide

F Fiorica, M Berretta, C Colosimo, A Stefanelli… - Archives of gerontology …, 2010 - Elsevier
The aim of this study was to evaluate the impact of radiotherapy plus concomitant and
adjuvant temozolomide (TMZ), in terms of feasibility and activity, in elderly patients with …

Treatment and outcomes for glioblastoma in elderly compared with non-elderly patients: a population-based study

ER Morgan, A Norman, K Laing, MD Seal - Current Oncology, 2017 - mdpi.com
Purpose: Elderly patients make up a large percentage of the individuals newly diagnosed
with glioblastoma (gbm), but they face particular challenges in tolerating standard therapy …

Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma

G Minniti, G Lanzetta, C Scaringi, P Caporello… - International Journal of …, 2012 - Elsevier
PURPOSE: Radiotherapy (RT) and chemotherapy may prolong survival in older patients
(age≥ 70 years) with glioblastoma multiforme (GBM), although the survival benefits remain …

Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme

AE Sijben, JB McIntyre, GB Roldán, JC Easaw… - Journal of neuro …, 2008 - Springer
Introduction Elderly patients have glioblastomas (GBM) that are aggressive and poorly
responsive to treatment. They are also prone to the side effects of treatment of GBM …

Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastoma

CA Barker, M Chang, JF Chou, Z Zhang, K Beal… - Journal of neuro …, 2012 - Springer
Survival of elderly patients with glioblastoma (GBM) is poor, but improves with tumor
resection and radiotherapy (RT). Concurrent temozolomide (TMZ) chemotherapy during RT …

Glioblastoma (GBM) in elderly patients: A randomized phase III trial comparing survival in patients treated with 6-week radiotherapy (RT) versus hypofractionated RT …

A Malmstrom, BH Grønberg, R Stupp… - Journal of Clinical …, 2010 - ascopubs.org
LBA2002 Background: Despite treatment advances, survival of elderly GBM patients (pts) is
usually< 12 months. Hypofractionated RT is advocated in order to shorten treatment time …

Aggressive treatment is appropriate for glioblastoma multiforme patients 70 years old or older: a retrospective review of 206 cases

JG Scott, JH Suh, P Elson, GH Barnett… - Neuro …, 2011 - academic.oup.com
Elderly patients have largely been excluded from randomized trials for glioblastoma
multiforme (GBM). We reviewed the results of treatment approaches, which included …