The etiological role of NSD2 enzymatic activity in solid tumors is unclear. Here we show that
NSD2, via H3K36me2 catalysis, cooperates with oncogenic KRAS signaling to drive lung …

The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse
diseases and commonly overexpressed in multiple myeloma due to a recurrent t (4; 14) …

Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been
implicated in the aetiology of lung squamous cell carcinoma (LUSC),–. The FGFR1 gene is …

The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid
tumors but its contribution to the biology of these tumors is not well understood. Here, we …

Histone methyltransferase NSD3 is frequently dysregulated in human cancers, yet the
epigenetic role of NSD3 during cancer development remains elusive. Here we report that …

Epigenetic dysregulation has emerged as a major contributor to tumorigenesis. Histone
methylation is a well-established mechanism of epigenetic regulation that is dynamically …

Malignant solid tumors are the leading cause of death in humans, and epigenetic regulation
plays a significant role in studying the mechanism of human solid tumors. Recently, histone …

More than 90% of small cell lung cancers (SCLCs) harbor loss-of-function mutations in the
tumor suppressor gene RB1. The canonical function of the RB1 gene product, pRB, is to …

Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD)
family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are …

The readout of histone modifications plays a critical role in chromatin-regulated processes.
Dimethylation at Lys-36 on histone H3 (H3K36me2) is associated with actively transcribed …