Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive
unfolded protein response (UPR), but that beyond a certain degree of ER damage, this …

Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR)
that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

Cellular stress, induced by external or internal cues, activates several well-orchestrated
processes aimed at either restoring cellular homeostasis or committing to cell death. Those …

The endoplasmic reticulum (ER) is the primary site for synthesis and folding of secreted and
membrane-bound proteins. Proteins are translocated into ER lumen in an unfolded state …

The endoplasmic reticulum (ER) and mitochondria form physical interactions involved in the
regulation of biologic functions including mitochondrial bioenergetics and apoptotic …

Over the past years, knowledge and evidence about the existence of crosstalks between
cellular organelles and their potential effects on survival or cell death have been constantly …

Abrogation of endoplasmic reticulum (ER) protein folding triggered by exogenous or
endogenous factors, stimulates a cellular stress response, termed ER stress. ER stress re …

Protein misfolding in the endoplasmic reticulum (ER) is accompanied by adaptive cellular
responses to promote cell survival. We now show that activation of mitochondrial respiration …

Mitochondria are required for numerous essential metabolic processes including the
regulation of apoptosis; therefore, proper maintenance of the mitochondrial proteome is …