The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

The ability to create thick tissues is a major tissue engineering challenge, requiring the
development of a suitable vascular supply. Current trends are seeing the utilization of cells …

One of the main limitation in obtaining thick, 3-dimensional viable engineered constructs is
the inability to provide a sufficient and functional blood vessel system essential for the in …

Although there have been extensive research efforts to create functional tissues and organs,
most successes in tissue engineering have been limited to avascular or thin tissues. The …

Neovascularisation is a promising alternative therapeutic approach to re-establish blood
flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery …

• Introduction• Components of blood vessel• Principle of vessel engineering• Seeding cells
sources‐Autologous ECs and SMCs‐Embryonic stem cells‐Adult stem cells‐Other cell …

Long-term viability of thick three-dimensional engineered tissue constructs is a major
challenge. Addressing it requires development of vessel-like network that will allow the …

Blood vessels transport blood to deliver oxygen and nutrients. Vascular diseases such as
atherosclerosis may result in obstruction of blood vessels and tissue ischemia. These …

Background/Purpose: The key challenge in tissue engineering is the establishment of an
efficient vascularization for tissue constructs guaranteeing long-term survival and function …

In vitro pre-vascularization is one of the main vascularization strategies in the tissue
engineering field. Culturing cells within a tissue-engineered construct (TEC) prior to …