Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease

H Liu, H Zhang, Y Ma - Mechanisms of ageing and development, 2021 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia globally. AD is a
progressive neurodegenerative disorder, eventually manifesting as severe cognitive …

[HTML][HTML] Adult hippocampal neurogenesis and its role in Alzheimer's disease

Y Mu, FH Gage - Molecular neurodegeneration, 2011 - Springer
The hippocampus, a brain area critical for learning and memory, is especially vulnerable to
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …

Adult hippocampal neurogenesis in Alzheimer's disease: an overview of human and animal studies with implications for therapeutic perspectives aimed at memory …

S Farioli-Vecchioli, V Ricci, S Middei - Neural Plasticity, 2022 - Wiley Online Library
The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural
stem cells. Newborn neurons integrate into existing neuronal networks, where they play a …

[PDF][PDF] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance

E Salta, O Lazarov, CP Fitzsimons, R Tanzi… - Cell Stem Cell, 2023 - cell.com
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Adult neurogenesis in Alzheimer's disease

SH Choi, RE Tanzi - Hippocampus, 2023 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of age‐related dementia, characterized
by progressive memory loss and cognitive disturbances. The hippocampus, where adult …

[HTML][HTML] Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer's disease

Y Zhou, X Wang, Y Liu, Y Gu, R Gu, G Zhang… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a degenerative disease of the central nervous system, the most
common type of dementia in old age, which causes progressive loss of cognitive functions …

Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's disease

P Chen, ZL Guo, B Zhou - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia and seriously affects the
quality of life of the elderly. Neurodegeneration is closely related to hippocampal dysfunction …

[HTML][HTML] Adult hippocampal neurogenesis and its impairment in Alzheimer's disease

TA Kim, MD Syty, K Wu, S Ge - Zoological research, 2022 - ncbi.nlm.nih.gov
Adult neurogenesis is the creation of new neurons which integrate into the existing neural
circuit of the adult brain. Recent evidence suggests that adult hippocampal neurogenesis …

Untold new beginnings: adult hippocampal neurogenesis and Alzheimer's disease

CM Teixeira, N Pallas-Bazarra, M Bolós… - Journal of …, 2018 - content.iospress.com
Neurogenesis occurs in a limited number of brain regions during adulthood. Of these, the
hippocampus has attracted great interest due to its involvement in memory processing …

[HTML][HTML] Alzheimer's disease and hippocampal adult neurogenesis; exploring shared mechanisms

C Hollands, N Bartolotti, O Lazarov - Frontiers in neuroscience, 2016 - frontiersin.org
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life.
Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity …