Thyroid hormone (TH) signaling plays an important role in the regulation of long-wavelength
vision in vertebrates. In the retina, thyroid hormone receptor β (thrb) is required for …

We investigate mutations in trβ2, a splice variant of thrb, identifying changes in function,
structure, and behavior in larval and adult zebrafish retinas. Two N-terminus CRISPR …

Thyroid hormone (TH) is essential in numerous physiological functions and developmental
processes. It acts through TH receptors (TRs) to regulate gene expression. The retina is the …

Vertebrate color vision requires spectrally selective opsin-based pigments, expressed in
distinct cone photoreceptor populations. In primates and in fish, spectrally divergent opsin …

Thyroid hormone (TH) and retinoic acid (RA) are powerful modulators of photoreceptor
differentiation during vertebrate retinal development. In the embryos and young juveniles of …

Otx family homeoproteins Otx2 and Crx are expressed in photoreceptor precursor cells and
bind to the common DNA-binding consensus sequence, but these two proteins have distinct …

Thyroid hormone appears to play a critical, yet not fully understood, role in the development
of the neuroretina. This review focuses on recent experiments in the rodent, chicken, and …

Thyroid hormone and its receptors (TRs) regulate photoreceptor differentiation and visual
pigment protein (opsin) expression in the retinas of several vertebrates, including rodents …

Color vision is facilitated by distinct populations of cone photoreceptors in the retina. In
rodents, cones expressing different opsin photopigments are sensitive to middle (M,'green') …

Purpose: Investigate the effects of systemic hypothyroidism upon the differentiated, growing,
and regenerating retina of postmetamorphic winter flounder, a vertebrate that experiences a …