The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …

There are significant economic incentives to transition from batch to continuous processing
of pharmaceutical products. However, several challenges must be overcome in order to …

Highlights•Continuous processing represents new challenges in pharmaceutical material
science.•Critique of key process steps such as feeding on product quality has …

The pharmaceutical industry currently faces economic and regulatory challenges associated
with process development. Process modeling tools can play a role in developing robust and …

Context: Continuous processing is an innovative production concept well known and
successfully used in other industries for many years. The modern pharmaceutical industry is …

In this work, a dynamic flowsheet model for the production of pharmaceutical tablets through
a continuous wet granulation process is developed. The unit operation models which are …

This study reviews process modeling efforts which have been developed to elucidate the
fundamental physical process underlying the manufacture and delivery of pharmaceutical …

Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …

The pharmaceutical industry is a global business sector with $1 trillion annual sales focused
on performancebased products designed to address the health care needs of the world's …

Research emphases on extensive experimental studies and modeling efforts have been on
the rise for the development of accurate predictive models of pharmaceutical unit operations …