The Golgi apparatus (GA) is the hub of intracellular trafficking, but selectively targeting GA
remains a challenge. We show an unconventional types of peptide thioesters, consisting of …

Changing an oxygen atom of the phosphoester bond in phosphopeptides by a sulfur atom
enables instantly targeting Golgi apparatus (GA) and selectively killing cancer cells by …

Self-sorting is a common phenomenon in eukaryotic cells and represents one of the
versatile strategies for the formation of advanced functional materials; however, developing …

Peptide hormones are attractive as injectable therapeutics and imaging agents, but they
often require extensive modification by mutagenesis and/or chemical synthesis to prevent …

In this study, we demonstrate that appendage of a single asparagusic acid residue (AspA
tag) is sufficient to ensure efficient cellular uptake and intracellular distribution of fully …

Cell-penetrating peptides (CPPs) are routinely used for the delivery of macromolecules into
live human cells. To enter the cytosolic space of cells, CPPs typically permeabilize the …

Hydrocarbon-stapled α-helical peptides are a new class of targeting molecules capable of
penetrating cells and engaging intracellular targets formerly considered intractable. This …

Exosomes are secreted extracellular vesicles that mediate intercellular transfer of cellular
contents and are attractive vehicles for therapeutic delivery of bimolecular cargo such as …

Proteins that engage in intracellular interactions with other proteins are widely considered
among the most biologically appealing yet chemically intractable targets for drug discovery …

Hydrocarbon-stapled peptides are a class of bioactive alpha-helical ligands developed to
dissect and target protein interactions. While there is consensus that stapled peptides can …