Acetylation of K40 in α-tubulin is the sole posttranslational modification to mark the luminal
surface of microtubules. It is still controversial whether its relationship with microtubule …

The αβ-tubulin subunits of microtubules can undergo a variety of evolutionarily-conserved
post-translational modifications (PTMs) that provide functional specialization to subsets of …

Background Microtubules are built from linear polymers of α-β tubulin dimers
(protofilaments) that form a tubular quinary structure. Microtubules assembled from purified …

Tubulin undergoes posttranslational modifications proposed to specify microtubule
subpopulations for particular functions. Most of these modifications occur on the C-termini of …

Microtubules are structural polymers inside of cells that are subject to posttranslational
modifications. These posttranslational modifications create functionally distinct subsets of …

Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in
cell division and in organizing cell cytoplasm. Although they have been discovered more …

Microtubules are essential to neuron shape and function. Acetylation of tubulin has the
potential to directly tune the behavior and function of microtubules in cells. Although …

Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known
posttranslational modification in the microtubule lumen. It marks stable microtubules and is …

Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 …

Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While
long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place …