Cytotoxicity, apoptosis inducing activity and Western blot analysis of tanshinone derivatives from Stachys parviflora on prostate and breast cancer cells

A Shakeri, T Hafezian, N Kúsz, J Hohmann… - Molecular Biology …, 2022 - Springer
Cytotoxic activities of methanolic crude extract of Stachys parviflora (Lamiaceae family) and
its sub-fractions were primarily evaluated against human breast adenocarcinoma (MCF-7 …

Tanshinone IIA shows higher antiproliferative activities than Sinapic acid in 4 cancer cell lines and simultaneously induces apoptosis and necroptosis in human lung …

CY Lin, M Tam Ly, SH Yang, SC Lai… - Natural Product …, 2021 - journals.sagepub.com
Tanshinone IIA (Tan IIA) and sinapic acid (SA) are 2 components separately isolated from 2
Asian medicinal plants, Hydnophytum formicarum Jack and Salvia miltiorrhiza Bunge. The …

15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies

JJ Liu, HH Wu, TH Chen, W Leung… - International journal of …, 2015 - mdpi.com
15, 16-Dihydrotanshinone I (DHTS) is extracted from Salvia miltiorrhiza Bunge which is a
functional food in Asia. In this study, we investigated the apoptotic effect of DHTS on the …

Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells

TL Pan, YC Hung, PW Wang, ST Chen, TK Hsu… - …, 2010 - Wiley Online Library
Certain antitumor agents have recently been extracted from the roots of Salvia miltiorrhiza
Bunge. The diterpene derivative, tanshinone IIA, possesses cytotoxic activity against several …

Biological activity of dihydrotanshinone I: effect on apoptosis

DS Lee, SH Lee - Journal of bioscience and bioengineering, 2000 - Elsevier
Recently, we have found for the first time that dihydrotanshinone I, isolated from Salvia
miltiorrhiza, exhibited cytotoxicity against various tumor cell lines. To investigate whether the …

Stephanthraniline A suppresses proliferation of HCT116 human colon cancer cells through induction of caspase-dependent apoptosis, dysregulation of mitochondrial …

L Wang, L Yao, X Li, J Chen, C Lou… - The Journal of …, 2019 - jstage.jst.go.jp
Stephanthraniline A (STA) is a C 21 steroidal aglycone isolated from the stem of Stephanotis
mucronata (Blanco) Merr. that exerts growth inhibition in human colon cancer cells …

Dihydrotanshinone induces apoptosis of SGC7901 and MGC803 cells via activation of JNK and p38 signalling pathways

R Cheng, J Chen, Y Wang, Y Ge, Z Huang… - Pharmaceutical …, 2016 - Taylor & Francis
Abstract Context: Dihydrotanshinone (DHT), a natural compound from Salvia miltiorrhiza
Bunge (Lamiaceae), showed higher cytotoxic potential compared with other tanshinones. Its …

Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells

ZK Dai, JK Qin, JE Huang, Y Luo, Q Xu… - Journal of natural …, 2012 - Springer
Abstract Tanshinone IIA (Tan IIA), a natural product from herb Salvia miltiorrhiza Bunge, has
potential anti-tumor activity. The aim of this study was to pinpoint the molecular mechanisms …

Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios

CC Su, YH Lin - International journal of molecular …, 2008 - spandidos-publications.com
Tanshinone IIA (C19H18O3) was extracted from danshen (Salviae miltiorrhizae radix). It has
cytotoxic properties and induces apoptosis in many human cancer cells. The molecular …

A novel tanshinone analog exerts anti-cancer effects in prostate cancer by inducing cell apoptosis, arresting cell cycle at G2 phase and blocking metastatic ability

M Wang, X Zeng, S Li, Z Sun, J Yu, C Chen… - International Journal of …, 2019 - mdpi.com
Prostate cancer (PCa), an epithelial malignant tumor, is the second common cause of
cancer death among males in western countries. Thus, the development of new strategies is …